COMPOSITION  

Each 5 ml contains:
Alcohol USNF 0.26 g (n-Butanol)
Citric Acid I.P. 0.0025 g
Physiological saline soln. 3.1 ml
Water for injection I.P. q.s.

REVICI is named after its inventor Dr.Emanual Revici of USA.

• n-Butanol exerts an increased muscular contraction on the muscular walls of the bleeding vessels and thus brings about stoppage of the acute haemorrhage. n-Butanol inhibits enzymes like proteolytic enzyme present in plasmin and delays retraction of blood clots. In addition it acidifys the site of damage, thereby preventing the condition of alkalosis. Alkalosis of the blood vessels causes excessive bleeding and pain. Hence, Revici also acts as an analgesic.
  

• Citric Acid, which is a rich source of Vitamin-C, helps in capillary integrity and increases resistance to haemorrhage.Since revici is  in injectable form, it reaches unchanged to the site of action. It is metabolised mainly in the liver by enzyme dehydroxygenase. The metabolites do not have any harmful action and are excreted in urine.
  


SAFETY OF  REVICI

REVICI injection has the highest safety margin because of higher therapeutic index (75-100)
Hence, very high dosages as & when required can be given to achieve the result.

Therapeutic index is the ratio between LD50 & ED50.

LD50: Lethal dose - a dose at which alteast 50 % of the selected group die.
ED50: Effective dose - a dose at which alteast 50 % of the selected group shows the
effect of the drug.

INDICATIONS


• External & internal haemorrhages

• All surgical procedures

• Dentistry

• Pre & post operative haemorrhages

• Obstetrics & Gynaecology

                      -> Metrorrhagia

                      -> Dysfunctional uterine bleeding

                      -> Post-partum haemorrhage

                      -> Haemorrhage associated with IUCD.

DOSAGE
1 ampoule of 5 ml 3 times daily or as & when required.

CONTRAINDICATIONS
No contraindications are known so far but it should be used with caution in patients with severe hepatic dysfunction.