Methylcobalamin is a type of Vitamin B12. Vitamin B12 comes in several kinds including hydroxy-, cyano-, and adenosyl-, but only the methyl and adenosyl forms are active within the body. Deficiency occurs from a lack of "intrinsic factor" a mucoprotein enzyme in gastrointestinal tract,from tapeworm infestation or excessive bacteria in stomach and intestines.
Methylcobalamin donates methyl groups to the myelin sheath that insulates nerve fibres and regenerates damaged neurons. In a B12 deficiency, toxic fatty acids destroy the myelin sheath but high enough doses of B12 can repair it.

Folic acid (Vitamin B9), a member of the B-complex vitamins, is a water-soluble vitamin that is unstable in heat and light.
Folic acid is required for DNA synthesis and cell growth and is important for red blood cell formation, energy production as well as the forming of amino acids. Folic acid is essential for creating haeme, the iron containing substance in hemoglobin, crucial for oxygen transport. It is important for healthy cell division and replication, since it is acts as a coenzyme for RNA and DNA synthesis. It is also required for protein metabolism and in treating folic acid anemia. Folic acid also assists in digestion, and the nervous system, and works at improving mental as well as emotional health. This nutrient may be effective in treating depression and anxiety. Folic acid is very important in the development of the nervous system of a developing fetus.

Vitamin B6 is a water-soluble vitamin that exists in three major chemical forms: pyridoxine, pyridoxal, and pyridoxamine. It performs a wide variety of functions in our body and is essential for our good health. Vitamin B6 is needed for more than 100 enzymes involved in protein metabolism. It is also essential for red blood cell metabolism. The nervous and immune systems need vitamin B6 to function efficiently, and it is also needed for the conversion of tryptophan (an amino acid) to niacin (a vitamin).

 Alpha Lipoic Acid  chemically is 1,2-dithiolane-3-pentanoic acid. It is a sulphur containing substance, which is readily converted from its reduced state, dihydrolipoic acid. It can be found in foods such as meats and spinach. It is readily absorbed in the blood stream and can also cross blood brain barrier.

It functions as a cofactor for enzymes involved in conversion of energy from glucose and fats, Krebs cycle (metabolism of fats and carbohydrates). It lowers blood sugar. It is a powerful antioxidant and prevents cellular damage from free radicals thereby reducing oxidative stress. It increases production of glutathione, which helps dissolves toxic substances in liver.

INDICATIONS
Diabetic Neuropathies, Peripheral Neuropathies,Hyperhomocytemia,Megaloblastic anemia,Vit.B12 deficiency Infections,Neurological pain, Sensory disturbances, Rheumatoid Arthritis,Osteoporosis, Gout,Mood disorder,Sleep disturbances, Alzheimer's Disease , Multiple sclerosis, Parkinson's disease, Heart rate variability, Fibromyalgia , Bell's palsy, Herpes Zoster , Cancer,  HIV

DOSAGE & ADMINISTRATION

Keenuron Inj
Peripheral neuropathies: 1 amp. administered IM or IV 3 times a week. The dosage may be adjusted depending on the patient's age and symptoms.
Megaloblastic Anemia: 1 amp administered IM or IV 3 times a week.
After about 2 months of medication, the dose should be reduced to a single administration of 1 amp at 1-3 months intervals for maintenance therapy.

Keenuron 

3 capsules a day in equally divided doses or as recommended by the physician.

Keenuron OD
1 capsule a day or as recommended the physician

CONTRAINDICATIONS

Hypersensitivity to any ingredient of the composition
Methylcobalamin: Anaphylactic reaction and other sensitivity reactions
Tobacco amblyopia
Folic acid: Addisonian pernicious anemia, malignant disease.
Pyridoxine Hcl: concomitant administration of levodopa.