The
process of arresting bleeding is called Haemostasis. The agent
which helps in this process is a Haemostat.Haemostasis comprises of
4 events
Vasoconstriction
When bleeding occurs due to damaged blood vessel, platelets present in
blood come together to the site of injury. They become sticky and release
"SEROTONIN", which constricts (narrows) the blood vessel, thereby reducing
blood flow.
Platelet Plug formation
Platelets attract themselves at the damaged site. They release many substances
mainly ADP (Adenosine Diphosphate) and this quickly attracts more platelets
to this site. This accumulation of platelets quickly forms a temporary
seal called 'platelet plug'. Thus, blood loss through vascular opening
is stopped.
Coagulation
It is a complex process which involves many factors. It is described in
a simplified manner as given below: -
Thromboplastin is liberated from the damaged tissues and damaged platelets.
This converts inactive Prothrombin, in the presence of Ca ions (Ca++)
into active thrombin.Thrombin converts soluble fibronogen in the presence
of Ca++ into insoluble fibrin.These are protein fibres that form a mesh
where blood cells get entrapped and thus form a blood clot.
Clot
Dissolution
Once the blood
clot is formed, clot retraction starts. Plasminogen present in
blood is activated to form plasmin which brings about lysis of fibrin
clot thereby causing clot dissolution. |