Bidoflox-OZ has in vitro activity against a broad spectrum of gram-positive and gram-negative aerobic and anaerobic bacteria.

Ofloxacin is thought to exert a bactericidal effect on susceptible microorganisms by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication, transcription, and repair of bacterial DNA.Ofloxacin has been shown to be active against most strains of the following microorganisms both in vitro and in specific clinical infections.
           

Gram-positive Aerobes: Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes.

Gram-negative Aerobes: Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Proteus mirabilis, Pseudomonas aeruginosa Other: Chlamydia trachomatis.

Ornidazole is a 5-nitroimidazole derivative with actions similar to Metronidazole and Tinidazole and is used in the treatment of susceptible Protozoal Infections and also in Anaerobic Bacterial Infections.

It is effective against Protozoa including Entamoeba histolytica, Giardia lambia and Trichomonas spp and Bacteria such as Bacteriodes spp., Anaerobic cocci, Fusobacterium spp., Clostridum spp., and Gardenerlla vaginalis. It acts by damage of DNA strands or inhibition of their synthesis.

Both Ofloxacin and Ornidazole are almost completely absorbed from the small intestine when administered orally both having almost 100% bioavailability. Subsequent plasma concentrations of Ofloxacin are obtained in 1-2 hours after oral administration. Peak plasma concentrations of Ornidazole are obtained within 2 hours of administration.

The plasma elimination of Ornidazole is 12 to 15 hours and less than 15% is bound to plasma proteins. It is widely distributed in body tissues and fluids. Ornidazole is metabolised in the liver and is excreted in the urine mainly as metabolites and conjugates and to a lesser extent in the faces.

INDICATIONS
Bidoflox-OZ is indicated for the treatment of a wide variety of infections caused by susceptible gram-positive and gram-negative organisms along with anaerobes and protozoa.    

• Gynaecological infections including prophylaxis in gynaecological surgeries. 

• Surgical prophylaxis and surgical wound infections.

• Respiratory tract infections like lung abscess, aspiration pneumonia, empyema and bronchiectasis      

• ENT infections like chronic sinusitis, chronic suppurative otitis media,
  cholesteatoma and mastoiditis.

• Orofacial and dental infections.

•  Dermatological infections like cellulitis, breast and other cutaneous abscesses, angrene, diabetic and decubitus ulcers.

•  Intra-abdominal infections and diarrhoeas of mixed bacterial and protozoal origi